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The Binding of Isaac Rebirth – Pickups and Consumables Guide


Consumables are pickups that disappear after use

Consumables include:

  • Tarot Cards
  • Playing Cards
  • Special Cards
  • Runes
  • Pills

Tarot Cards

Tarot Cards are the most common card pickup. There are 21 diffirent tarot cards in the game.

0 – The Fool
Teleports you to the spawn room

I – The Magician
Gives you homing shots for one room

II – The High Priestess
Spawns Mom’s Foot which targets an enemy with most health, dealing 400 damage to it afterwards, basically enough damage to one-shot any enemy. If used in an empty room, the foot targets Isaac instead.

III – The Empress
Gives you the ♥♥♥♥♥ of Babylon effect for one room

IV – The Emperor
Teleports you to the boss room

V – The Hierophant
Spawns 2 soul hearts around the player

VI – The Lovers
Spawns two normal hearts around the player. Can be used in a Cellar Top Secret Room to give you 2 black hearts or in a Cathedral Top Secret Room to give you 2 eternal hearts

VII – The Chariot
Gives you the My Little Unicorn effect

VIII – Justice
Spawns a key, bomb, coin and a heart around the player. The heart can sometimes turn into any heart type

IX – The Hermit
Teleports you into a shop. Upon leaving it the door to it will be opened without using a key, although leaving through a secret room will leave it locked

X – Wheel of Fortune
Spawns a Slot Machine

XI – Strength
Increases all stats (except tears), size and adds one heart container for one room. Can be used to steal Devil deals

XII – The Hanged Man
Gives flight for one room

XIII – Death
Deals 40 damage to all enemies in the room

XIV – Temperance
Spawns a Blood Donation Machine

XV – The Devil
Gives the Book of Belial effect for one room

XVI – The Tower
Spawns 6 troll bombs in the room

XVII – The Stars
Teleports you to the Treasure Room. Teleports to a random room in The Womb I and beyond

XVIII – The Moon
Teleports you to the Secret Room. Can’t teleport to the Top Secret Room

XIX – The Sun
Deals 40 damage to all enemies in the room, fully heals Isaac and gives the Compass + Treasure Map effect for the entire floor

XX – Judgement
Spawns a beggar or a demon beggar

XXI – The World
Gives the Compass + Treasure Map effect for the entire floor

Playing Cards

Playing Cards are less common, yet they sometimes can have powerful, even run-changing effects.

Two of Clubs
Doubles your bomb count. If you have 0 bombs it will give you two bombs instead

Two of Diamonds
Doubles your money count. If you have 0 coins it will give you two coins instead

Two of Hearts
Probably most useless playing card. Doubles your red heart count. Basically, if you have one heart out of 3 heart containers it will multiply your current hearts by 2 making you have 2 hearts out of 3 heart containers. Useless on the ??? character

Two of Spades
Doubles your key count. If you have 0 keys it will give you two keys instead

Ace of Clubs
Converts all pickups in the room into bombs

Ace of Diamonds
Converts all pickups in the room into coins

Ace of Hearts
Converts all pickups in the room into hearts

Ace of Spades
Converts all pickups in the room into keys

Teleports you into a Deity Room (Angel/Devil Room)

Special Cards

Special Cards are cards that appear EVEN LESS OFTEN and have sometimes EVEN MORE POWERFUL OR EVEN RUN-CHANGING EFFECTS

See also:  The Binding of Isaac: Rebirth Trinkets Guide

Chaos Card
Kills EVERYTHING from enemies, bosses to even obstacles when thrown. (Move to the direction you want to throw and press Q). Can open normal doors and secret room entrances. Most effective when used on Hush’s 2nd stage or Delirium

Huge Growth
Makes Isaac huge for one room, also increasing his damage and range (basically a better Strength card)

Ancient Recall
Spawns 3 cards… that’s it

Era Walk
Slows enemies, increases Isaac’s speed and decreases his shot speed for one room

Credit Card
Gives you items that you have to pay for for free. Basically if you’d happen to see a really good devil deal.. for example Brimstone with the Pact, but you had little to no heart containers to buy the items, you could use your Credit Card (if you’d happen to have one) to get the items for free.

Double Active
Copies your active item effect on use

A Card Against Humanity
Fills the entire room with poop. When you exit the room before the process is done, it cancels it

Get Out Of Jail Free Card
Opens all doors adjacent to the room you’re currently in. Can open the Mega Satan door.

Holy Card
Gives you the Holy Mantle effect for one room

Emergency Contact
Spawns two Mom’s Hands that remove two random enemies from the room. If used on a boss, one hand will grab it making it “frozen” until it’s killed or the hand gives up.

Dice Shard
Rerolls all pickups and item pedestals in the room


Runes are consumables that appear rarely and have some powerful effects, one even game-breaking when combined with other items.

Runes are divided into two parts, left pointing runes and right pointing runes

Left pointing runes look like this: 
While right pointing runes look like this: 

Left pointing runes:

Destroys every obstacle in the room (except gaps)

Duplicates all pickups and chests in the room, combined with the Blank Card can result in a game-breaking combo

Creates a trapdoor to the next floor. The trapdoor can turn into a crawlspace

Removes all current curses and gives one soul heart

Right pointing runes:

Grants a shield for 30 seconds

Grants full map for the entire floor

Spawns 3 friendly flies and 3 friendly spiders

Rerolls all item pedestals in the room just like the D6

Blank Rune
Grants a random rune effect. 25% chance to spawn another Blank Rune after using it

Black Rune
Deals 40 damage to all enemies in the room, converts all pickups into friendly flies and spiders and turns item pedestals into random stat upgrades.


Pills are consumables that can give you temporary or permament status effects. They can be risky to take as one could screw up your entire run.

Pills can have 9 diffirent appearances in Rebirth with 4 more added in Afterbirth

Even though there are 46 pill effects only few are chosen, so it’s impossible to see every effect in one run

A pill that hasn’t been used before will show ??? as it’s name and will reveal it’s effect for the rest of the run after use (PHD will always show the pill effect no matter if it’s been used or not)

Pill effects:

Bad Gas:
Isaac farts, damaging and poisoning the enemies in short proximity around Isaac

Bad Trip:
Damages Isaac for one full heart. If Isaac has one heart or less it turns into a Full Health pill

See also:  The Binding of Isaac: Rebirth - It's the Key Achievement Guide

Balls Of Steel:
Gives Isaac 2 soul hearts

Bombs are Key:
Swaps the bomb count with the key count

Explosive Diarrhea:
Isaac lays five bombs at one a second

Full Health:
Refills Isaac’s red heart containers

Health Down:
Decreases Isaac’s red hear container count by 1. If Isaac has 1 red heart container it turns into a Health Up

Health Up:
Increases Isaac’s red heart container count by 1. Doesn’t fill the newly created heart container

I found pills:
Only cosmetic

Only cosmetic. If Isaac has consumed 3 of these pills he will turn into an adult giving him one heart container (Afterbirth+)

Pretty Fly:
Gives Isaac an orbital that blocks shots and damages fly-type enemies

Range Down:
Decreases range stat

Range Up:
Increases range stat

Speed Down:
Decreases speed stat

Speed Up:
Increases speed stat

Tears Down:
Decreases tears stat

Tears Up:
Increases tears stat

Luck Down:
Decreases luck stat

Luck Up:
Increases luck stat

Teleports Isaac to a random room. 6.66% chance to teleport into the I AM ERROR room

48 Hour Energy:
Generates 1-2 batteries

Drains Isaac’s red health to one heart (not containers) and spawns 1-4 red hearts

Stops Isaac for a short time

I can see forever!:
Grants the X-Ray Goggles effect for one floor

Charms all enemies in the room

Grants Curse of the Lost for one floor. Can stack with other curses

Lemon Party:
Spawns a large puddle of creep around Isaac which damages enemies

R U a Wizard?:
Gives the dunce cap effect for one minute

All damage damages Isaac for only half a heart no matter what for one room

Isaac takes a full heart from any damage source for one room

Spawns poop under Isaac’s a$$ feet

Gives the Curse of the Maze for one floor

One makes you larger:
Increases Isaac’s size and lowers pitch. Hitbox doesn’t change

One makes you small:
Decreases Isaac’s size and increases pitch. Hitbox is smaller

Destroys every poop and spawns a friendly spider instead of it.

Spawns friendly spiders based on the number of enemies in the room. If no enemies are present, the pill spawns 1-3 friendly spiders

Power Pill!:
Gives the Gamekid effect

Retro Vision:
Pixelates the screen 3 times for 3 seconds every 30 seconds

Friends till the end!:
Spawns 3 friendly flies

Creates a puddle of slippery brown creep around Isaac

Something’s wrong:
Spawns a puddle of black creep around Isaac

I’m Drowsy:
Slows enemies for one room

I’m Excited!:
Speeds up enemies for one room

Destroys the trinket Isaac is currently holding and applies it’s effects to the player

Spawns a consumable Isaac previously used. If Isaac used no consumables before it will spawn the Vurp! pill again

Upon use Isaac spits out an Ipecac shot which deals 200 damage

Feels like I’m walking on the sunshine!:
Gives the Unicorn Stump effect


Pickups are entities that go towards your pickup count (keys, bombs, coins) once you pick them up, or do something else (like Batteries and Hearts).

Pickup count can’t go above 99


Hearts are things which keep you alive. As in any other game, when you reach no life, you die. In Rebirth and beyond there is a heart cap at 12 hearts. In the original The Binding Of Isaac: Wrath of The Lamb you could have as many hearts as you’d like. In the original original The Binding Of Isaac the extra hearts just went off screen.The Deity Room chance mostly revolves around not taking red heart damage on the floor, so something like soul/black hearts can “protect” your devil deal.

Red hearts:

Red hearts are hearts which upon pickup refill your heart containers. There are 3 types of red hearts:

See also:  The Binding of Isaac: Rebirth - It's the Key Achievement Guide

Half red hearts:
Refill half a heart container

Normal red hearts:
Refill one heart container

1+1 free hearts
Refill two heart containers

In Afterbirth+ there is also a Scared Heart. It looks like a normal heart, but when you get close to it, it “runs” away

Soul Hearts:

This is the most basic and common “armor” heart you can get. It works like a normal heart container but whenever it’s drained you can’t refill it anymore. Damage taken to these hearts doesn’t decrease your Deity Room chance.
There is also a half soul heart which is just a soul counterpart of the half red heart

Black Hearts:

A more useful cousin of the Soul Heart, the Black Heart whenever it’s drained, deals damage to enemies in the room, otherwise it functions like a soul heart

Eternal Heart:

A rare heart which is mostly found in the Cathedral Top Secret Rooms or just randomly spawned
These hearts when brought safely to the end of the floor, will give an additional heart container on the next one. It’s suggested to take the eternal heart after the boss fight or when you have a lot of armor hearts

Golden Heart:

An even rarer heart which drops around 7 coins after it’s “owner” heart is depleted. Any of these dropped coins can turn into a nickel or a dime

Bone Heart:

An Afterbirth+ exclusive heart which is an equivalent of 1.5 red hearts. After it’s depleted it disappears. The Forgotten character starts with these hearts.


Coins serve as a currency in shops and gambling machines in The Binding Of Isaac: Rebirth.

There are 5 types of coins in The Binding Of Isaac: Rebirth

Adds 1 to money count

1+1 Free
Adds 2 to money count

Adds 5 to money count

Adds 10 to money count

There are also lucky pennies which when picked up add 1 to the luck stat

There are also items which add to money count, for example The Quarter


Bombs are pickups that are dropped by using E and explode after a short amount of time
Bomb explosions can be used to:

  • Destroy obstacles (except gaps, key blocks and metal blocks)
  • Damage enemies
  • Open doors and Secret Room entrances

Bomb damageeffects and appearance can be changed by certain items including:

  • Hot Bombs
  • Bob’s Curse
  • Mr. Mega
  • Butt Bombs
  • Glitter Bombs

There are only 3 types of bomb pickups in The Binding Of Isaac: Rebirth

Normal bomb

Adds 1 to bomb count

1+1 Free Bomb

Adds 2 to bomb count

Golden Bomb

Grants access to infinite bomb for the rest of the floor

There are also troll bombs which can’t be picked up and explode in a short amount of time
There is also another troll bomb variant, a super troll bomb, which has a larger blast radius and follows the player until it explodes.


Keys are pickups which allow to access some of the game’s room mostly shown as a door with a lock.

Unlike bombs there are 4 types of keys in The Binding Of Isaac: Rebirth with one added in Afterbirth+

Normal key

Adds 1 to key count

1+1 Free Key

Adds 2 to key count

Golden Key

Grants access to infinite keys for the rest of the floor

Charged Key

Adds 1 to key count and charges your active item


Batteries are pickups which instantly recharge your active item
Unlike any other pickup, batteries have no other variants

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