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The Outer Worlds Auntie Cleo Quest Guide

Auntie Cleo Quest Guide

Auntie Cleo brings millenia of scientific research and advancement to your nearest pharmaceutical outlet or convenience store. With everything from their “Auntie-Biotics” line of medicinal solutions to their straight-from-the-laboratory Tripicale foodstuffs, you’re sure to find something for everyone.

Auntie Cleo: It’s Better than nature!

Reputation Bonus

Status Positive Reputation Negative Reputation Effects
Neutral 0% – 29% 0% – 29% None
Nervous +80% +80% None
Agreeable 30% – 49% 0% – 29% Vendor prices -5%
Tolerant +80% 50% – 79% Vendor prices -5%
Friendly 50% – 79% 0% – 29% Vendor prices -15%
Understanding +80% 30% – 49% Vendor prices -15%
Revering +80% 0% – 29% Vendor prices -25%
Agitated 50% – 79% +80% Vendor prices +10%
Bitter 30% – 49% 50% – 79% Vendor prices +10%
Repulsed 0% – 29% +80% Vendor prices +50% – They will attack on sight.
  • Anton Crane
  • Berke
  • Cassandra O’Malley
  • Jameson
  • Weldon
  • Vaughn Cortes
  • Orson Shaw
  1. By His Bootstraps
  2. Vulcan’s Hammer
  3. The Amateur Alchemist
  4. The Doom That Came to Roseway

1. By His Bootstraps Walkthrough

You will obtain this quest after landing in Roseway and entering the town. Find and talk to Anton Crane, and he will mention he left his protege at the lab during the commotion. Accept to rescue the labcoat to begin the quest.

Exit the town toward Roseway Gardens, and defeat the Raptidon that attack you as you approach Auntie-Biotics Lab 0013. Go inside, and you’ll find a Vending Machine and a terminal that can be hacked to unlock the hallway lift, and you can read the Storage Facility Passcode. If you cannot hack it, take the left door from the entrance and make your way to the upper level or you can Lockpick the door on the right.

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On the second floor, defeat several Raptidon and then loot Elite Troop Armor from a Corporate Commander corpse. An unlocked door nearby leands to an office. Within the office, pick up Gigantaur Energy Drink and interact with the terminal by it to learn about the Raptidon experiment. You can loot Standard Troop Helmet and a container.

Back in the large office where you fought the Raptidons, a locked door can be opened with Cleo Lab Office Keycard, or sufficient lockpicking. Once you’ve unlocked the door, you can go in and talk to Jameson. He recognizes you and asks you what you’re doing here. Tell him Anton sent you and he’ll complain that Anton is always double-checking everything he does. Jameson says that Anton does not care about him and instead just wants the precursors that he is holding. You can bring up that employee death would look back for Anton, ask him for the item to test the theory, or just get going.

Tell him about employee death: You will get 8250xp and Jameson will run off

Return to Anton and talk to him to gain Auntie Cleo Reputation, 1000 Bit Cartridge and 11,000xp.

Alternative outcome
It is possible to be too late to save Jameson. It is uncertain exactly what the cut off is, but if you have already been to the other labs, you may enter the facility and find the door shredded by the Raptidons. If so, Jameson will have been mauled to death.

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You can retrieve his keycard for 9000xp.

Returning to Anton you will get a somber reaction, 9000xp, 625xp, and a minor Auntie Cleo reputation loss.

2. Vulcan’s Hammer Walkthrough

Speak to Orson Shaw near the Workbench in Roseway to gain this quest. Head out of Roseway to the south and make your way to the Storage Facility. Once there, defeat the marauders and you will come to an Armory Door that is locked. You need Storage Facility Passcode from Auntie-Biotics Lab to get in.

Come back with the code and loot the FORCE Pistol Schematics from the basement (it’s on the wall, 11000xp). You’ll find the Acid Steeper on the way there on a shelf, just above where the schematics will be found. You’ll need the Steeper for The Cleaning Machine quest.

Return to either Orson or Gladys for your reward. If you return to Orson, ask why he didn’t turn in this contraband. You can Intimidate or Persuade (45) him to get him to buy the weapon for 100 Bit Cartirdge, but you’ll lose Auntie Cleo Reputation (5% negative).

Remaining in good standing with Orson is advisable, as he’ll later give you the Unique Weapon: Ulti-Nature.

3. The Amateur Alchemist Walkthrough

You will obtain this quest when you arrive in Roseway as part of The Distress Signal, if you go into the Auntie Cleo apartments area and talk to Vaughn Cortes. Accept his request for aid to start the quest.

You’ll need to head to the Cover Labs, outside Roseway by a good ways to the southeast. Once inside you’ll need to fight your way through the Outlaws and Raptidons in order to get to Vaughn’s Research. This will overlap with The Distress Signal and The Doom That Came to Roseway quests. Once inside the lab use the terminal to decide what to do with the data.

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Recalibrate Experiment (Science 50) yields Raptidon Musk x2, allowing you to give two samples out rather than one.

Extract Sample gives you 1 Raptidon Musk.

This area also has the Unique Weapon: Rapti-prod

Once you have the data you’ll have to decide who to give it to: Vaughn, Anton or Gladys. If you have only one sample, you can only give it to one, and if you do give it to Gladys, you will Botch the quest. Either Vaughn or Anton will complete it, still giving you XP.

If you return to Vaughn you have the option to give him 2 samples or lie (45) to keep half. You’ll get 8250xp, and 11000 xp, plus Auntie Cleo Reputation for completing the quest. You can also ask for 1875 Bit Cartridge.

4. The Doom That Came To Roseway Quest

After speaking with Gladys on the Groundbreaker, she gives you a Distress call. Return to the ship and speak with ADA to play it. Travel to Terra 2, Roseway. There’s quite a few objectives here but they are all easy enough to follow. There are some optional objectives.
Dealing with the Raptidons. There’s a queen in one of the rooms. You must gather some items from nearby and gas the room for that objective.



When you run into Cassandra, agree to help her. Clear the paths, speak with security etc. Once she is free, you can convince her to give the research or kill her. If you save the queen, take out the mercs, and get the research, you get a lot of XP, Bits and Auntie Cleo rep.

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